Zur Wirkung von Kadmium auf Gewebsatmung und Glukoneogenese in der Nierenrinde von Ratten

✍ Scribed by Wolfgang Seiller; Heinrich Echsel; Max Hohenegger

• Publisher: Springer-Verlag
• Year: 1978
• Tongue: English
• Weight: 328 KB
• Volume: 42
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00353714

✦ Synopsis

Oxygen consumption (QO2), respiratory quotient (RQ) and gluconeogenesis of rat kidney cortex slices were determined (Warburg technique). QO 2 was not infuenced by 0.01 mM CdCl 2 in the incubation medium (no exogenous substrate added), 0.1 mM, 1 mM and 10 raM, respectively, reduced QO 2 by 43%, 45% and 68%. In the presence of 8 mM glucose, 10 mM acetate or 5 mM buryrate, 1 mM Cd resulted in a decrease in QO~ by about 50% each. Addition of 20 g/1 albumine to the medium abolished this effect of cadmium. RQ was not influenced by 1 mM Cd, both without and with 8 mM glucose in the medium. Glucose production from 7 mM pyruvate or 5 mM glutaminate in slices from fed an starving rats was reduced by 1 mM Cd to half the value found in controls.