Zinc-mediated acylation and sulfonation of pyrrole and its derivatives

✍ Scribed by J.S. Yadav; B.V.S. Reddy; G. Kondaji; R. Srinivasa Rao; S. Praveen Kumar

• Book ID: 104252146
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 162 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01914-7

✦ Synopsis

Pyrrole and its derivatives react smoothly with acid chlorides and sulfonyl chlorides in the presence of zinc metal in toluene at ambient temperature to afford the corresponding 2-acetyl and 2-sulfonyl pyrrole derivatives in high yields with high regioselectivity.