Zatosetron, a 5-HT3 receptor antagonist in a multicenter trial for acute migraine
✍ Scribed by A.S. Chappell; J.M. Bay; G.D. Botzum; M.L. Cohen
- Book ID
- 116037691
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 442 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0028-3908
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## Abstract Zatosetron is a potent, orally active 5‐HT~3~ receptor antagonist with a long duration of activity in laboratory animals and humans. Several metabolites have been detected in plasma and urine of humans and experimental animals receiving zatosetron. The present study was designed to expl
## Abstract __Endo__‐5‐chloro‐2,3‐dihydro‐2,2‐dimethyl‐N‐(8‐methyl‐8 ‐azabicyclo‐[3.2.1.]‐oct‐3‐yl‐7‐benzofurancarboxamide‐[carbonyl‐^14^C] (Z)‐2‐butenedioate (zatosetron‐[^14^C] maleate, 1), has been prepared from 5‐chloro‐7‐bromo‐2,3‐dihydro‐2,2‐dimethylbenzofuran (5) in four radiochemical steps