Chronic Toxicity of Zatosetron, A 5-HT 3 Receptor Antagonist, in Rhesus Monkeys
✍ Scribed by Bendele, A.; Means, J.; Shoufler, J.; Schmalz, C.; Hanasono, G.; Symanowski, J.; Adams, E.
- Book ID
- 120820799
- Publisher
- Informa plc
- Year
- 1995
- Tongue
- English
- Weight
- 927 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0148-0545
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## Abstract Zatosetron is a potent, orally active 5‐HT~3~ receptor antagonist with a long duration of activity in laboratory animals and humans. Several metabolites have been detected in plasma and urine of humans and experimental animals receiving zatosetron. The present study was designed to expl
## Abstract __Endo__‐5‐chloro‐2,3‐dihydro‐2,2‐dimethyl‐N‐(8‐methyl‐8 ‐azabicyclo‐[3.2.1.]‐oct‐3‐yl‐7‐benzofurancarboxamide‐[carbonyl‐^14^C] (Z)‐2‐butenedioate (zatosetron‐[^14^C] maleate, 1), has been prepared from 5‐chloro‐7‐bromo‐2,3‐dihydro‐2,2‐dimethylbenzofuran (5) in four radiochemical steps