✦ LIBER ✦

XY gonadal dysgenesis and the H-Y antigen

✍ Scribed by Ulrich Wolf

Publisher: Springer
Year: 1979
Tongue: English
Weight: 554 KB
Volume: 47
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00321019

No coin nor oath required. For personal study only.

✦ Synopsis

H-Y antigen was determined in 12 patients affected by XY gonadal dysgenesis. Of these, three proved to be H-Y negative, and nine, including two sisters, were H-Y positive; two of the unrelated positive cases exhibited a reduced antigen titer. Therefore, this clinical condition must be genetically heterogeneous. It is assumed that in the negative cases and possibly in those with reduced antigen titer, the H-Y generating system is affected by mutation, while in the regular positive cases the target cells are unable to respond due to a defect of the gonad-specific H-Y antigen receptor.

📜 SIMILAR VOLUMES

H-Y antigen in Swyer syndrome and the ge

H-Y antigen in Swyer syndrome and the genetics of XY gonadal dysgenesis

✍ C. A. Moreira-Filho; S. P. A. Toledo; V. R. Bagnolli; O. Frota-Pessoa; H. Bisi; 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 871 KB

The H-Y antigen is a plasma membrane antigen involved in the organogenesis of the mammalian testis. Its expression on human cells is determined by a Y-linked gene. Phenotypic females affected by 46,XY gonadal dysgenesis (Swyer's syndrome) can be either H-Y-positive or H-Y-negative. In this paper we

H-Y antigen in 46,XY gonadal dysgenesis

✍ Stephen S. Wachtel; Gloria C. Koo; Albert Chapelle; Hanna Kallio; Joseph M. Heym 📂 Article 📅 1980 🏛 Springer 🌐 English ⚖ 550 KB

Gonadal tumor and H-Y antigen in 46,XY p

Gonadal tumor and H-Y antigen in 46,XY pure gonadal dysgenesis

✍ VÉRonique Amice; Jean Amice; Jean-Pierre Bercovici; Denise Riviere; Marie-Joséa 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 504 KB

Six cases of Swyer's syndrome (46,XY pure gonadal dysgenesis) are reported. Three patients, without gonadal tumor, had female H-Y antigen. Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. Repeated blood samples were obtained from two siblings. H-Y antigen level in t

Genetic heterogeneity of XY gonadal dysg

Genetic heterogeneity of XY gonadal dysgenesis (Swyer syndrome): H-Y antigen-negative XY gonadal dysgenesis associated with inflammatory bowel disease

✍ Passarge, Eberhard ;Wolf, Ulrich ;Opitz, John M. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 317 KB

XY gonadal dysgenesis: Genetic heterogen

XY gonadal dysgenesis: Genetic heterogeneity based upon clinical observations, H-Y antigen status and segregation analysis

✍ Joe Leigh Simpson; Natalie Blagowidow; Alice O. Martin 📂 Article 📅 1981 🏛 Springer 🌐 English ⚖ 707 KB

H-Y antigen in 46,XY pure testicular dys

H-Y antigen in 46,XY pure testicular dysgenesis

✍ Nazareth, H. R. S. ;Moreira-Filho, C. A. ;Cunha, A. J. B. ;Vieira-Filho, J. P. B 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 300 KB