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H-Y antigen in 46,XY gonadal dysgenesis

✍ Scribed by Stephen S. Wachtel; Gloria C. Koo; Albert Chapelle; Hanna Kallio; Joseph M. Heyman; Orlando J. Miller


Publisher
Springer
Year
1980
Tongue
English
Weight
550 KB
Volume
54
Category
Article
ISSN
0340-6717

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Six cases of Swyer's syndrome (46,XY pure gonadal dysgenesis) are reported. Three patients, without gonadal tumor, had female H-Y antigen. Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. Repeated blood samples were obtained from two siblings. H-Y antigen level in t

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The H-Y antigen is a plasma membrane antigen involved in the organogenesis of the mammalian testis. Its expression on human cells is determined by a Y-linked gene. Phenotypic females affected by 46,XY gonadal dysgenesis (Swyer's syndrome) can be either H-Y-positive or H-Y-negative. In this paper we