Six cases of Swyer's syndrome (46,XY pure gonadal dysgenesis) are reported. Three patients, without gonadal tumor, had female H-Y antigen. Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. Repeated blood samples were obtained from two siblings. H-Y antigen level in t
H-Y antigen in 46,XY gonadal dysgenesis
β Scribed by Stephen S. Wachtel; Gloria C. Koo; Albert Chapelle; Hanna Kallio; Joseph M. Heyman; Orlando J. Miller
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 550 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0340-6717
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H-Y antigen was determined in 12 patients affected by XY gonadal dysgenesis. Of these, three proved to be H-Y negative, and nine, including two sisters, were H-Y positive; two of the unrelated positive cases exhibited a reduced antigen titer. Therefore, this clinical condition must be genetically he
The H-Y antigen is a plasma membrane antigen involved in the organogenesis of the mammalian testis. Its expression on human cells is determined by a Y-linked gene. Phenotypic females affected by 46,XY gonadal dysgenesis (Swyer's syndrome) can be either H-Y-positive or H-Y-negative. In this paper we