Gonadal tumor and H-Y antigen in 46,XY pure gonadal dysgenesis

✍ Scribed by VÉRonique Amice; Jean Amice; Jean-Pierre Bercovici; Denise Riviere; Marie-Joséa Corolleur

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 504 KB
• Volume: 57
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19860401)57:7<1313::aid-cncr2820570710>3.0.co;2-k

✦ Synopsis

Six cases of Swyer's syndrome (46,XY pure gonadal dysgenesis) are reported. Three patients, without gonadal tumor, had female H-Y antigen. Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. Repeated blood samples were obtained from two siblings. H-Y antigen level in the first sibling, who presented with a gonadoblastoma and underwent a gonadectomy before the H-Y assays, was intermediate, and did not show any significant variation for 21 months. H-Y antigen level in the second sibling showed an increase in the male range, presumably due to the presence of gonadoblastomas. After resection of the tumors, H-Y antigen level became intermediate. These findings suggest a relation between the tumorization potentiality of the gonadal remnants and the H-Y antigen levels in 46,XY pure gonadal dysgenesis.