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X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor

✍ Scribed by Thunnissen, Marjolein M. G. M.; AB, Eiso; Kalk, Kor H.; Drenth, Jan; Dijkstra, Bauke W.; Kuipers, Oscar P.; Dijkman, Ruud; de Haas, Gerard H.; Verheij, Hubertus M.

Book ID
109766223
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
342 KB
Volume
347
Category
Article
ISSN
0028-0836

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Crystallization and preliminary X-ray di
Crystallization and preliminary X-ray diffraction studies of a toxic phospholipase A2 from the venom of Vipera ammodytes meridionalis complexed to a synthetic inhibitor
✍ Dessislava Nikolova Georgieva; Wojciech Rypniewski; Markus Perbandt; Mahendra Ja πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 86 KB

A toxic phospholipase A(2) (PLA(2)) is isolated from the neurotoxic complex Vipoxin, the major lethal component of the venom of Vipera ammodytes meridionalis. The enzyme is complexed to the synthetic inhibitor elaidoylamide and crystallized. The crystals belong to the space group P2(1)2(1)2(1), with