X chromosome inactivation in clinical practice
✍ Scribed by Karen Helene Ørstavik
- Book ID
- 106134849
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 416 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0340-6717
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X-chromosome inactivation is a paradigmatic epigenetic phenomenon that results in the mitotically heritable transcriptional inactivation of one X-chromosome in female mammals, thereby equalizing X-linked gene dosage between the sexes. The epigenetic factors and mechanisms that execute X-inactivation
X-chromosome inactivation refers to the coordinate regulation of almost all genes on the mammalian X chromosome. Most models for X chromosome inactivation suppose a role for methylation of X chromosome DNA sequences and/or the heterochromatinization of large 'domains' of the X chromosome containing