✦ LIBER ✦

X chromosome inactivation: A hypothesis

✍ Scribed by Michael W. McBurney

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 540 KB
Volume: 9
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950090211

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✦ Synopsis

X-chromosome inactivation refers to the coordinate regulation of almost all genes on the mammalian X chromosome. Most models for X chromosome inactivation suppose a role for methylation of X chromosome DNA sequences and/or the heterochromatinization of large 'domains' of the X chromosome containing many genes.' Some recent work concerning the expression of X-linked transgenes, and parallels between regulated expression of sex-linked genes in invertebrates and mammals, suggest that X chromosome inactivation may be a geneby-gene event mediated by the interaction between regulatory sequences common to all X-linked genes and soluble activators and repressors.

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