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Recent advances in X-chromosome inactivation

✍ Scribed by Sundeep Kalantry

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
291 KB
Volume
226
Category
Article
ISSN
0021-9541

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✦ Synopsis

X-chromosome inactivation is a paradigmatic epigenetic phenomenon that results in the mitotically heritable transcriptional inactivation of one X-chromosome in female mammals, thereby equalizing X-linked gene dosage between the sexes. The epigenetic factors and mechanisms that execute X-inactivation overlap with those that regulate embryonic development and disease progression, thus offering a window into the epigenetic processes that regulate development and disease. Here I summarize some recent developments as well as open questions in X-inactivation research.

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