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Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: A systematic review

✍ Scribed by L. Correia Guedes; J.J. Ferreira; M.M. Rosa; M. Coelho; V. Bonifati; C. Sampaio


Book ID
116820728
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
408 KB
Volume
16
Category
Article
ISSN
1353-8020

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To evaluate the frequency of the LRRK2 G2019S mutation in Italy, we tested 1,072 probands with Parkinson's disease (PD; 822 sporadic and 250 familial): 20 patients (1.9%) carried the G2019S mutation, 11 patients (1.3%) were sporadic, and 9 (4.3%) had a positive family history. Considering only proba

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## Abstract Among mutations associated with autosomal dominant and sporadic Parkinson's disease (PD) the G2019S substitution in the leucine‐rich repeat kinase 2 (LRRK2) gene is the most frequently identified. To estimate its frequency in Russia, we analyzed 208 patients with PD from the Northwester