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LRRK2G2019S mutation: frequency and haplotype data in South African Parkinson’s disease patients

✍ Scribed by Soraya Bardien; Angelica Marsberg; Rowena Keyser; Debbie Lombard; Suzanne Lesage; Alexis Brice; Jonathan Carr

Publisher
Springer
Year
2010
Tongue
English
Weight
270 KB
Volume
117
Category
Article
ISSN
1435-1463

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## Abstract Mutations in the Leucine‐Rich Repeat Kinase 2 gene (__LRRK2__) are mainly responsible for idiopathic Parkinson's disease (PD) with either a dominant pattern of transmission or a sporadic occurrence due to the reduced penetrance. A majority of __LRRK2__ kindreds demonstrate an extremely