Woodchuck hepatitis virus DNA integration in a common chromosomal region of the woodchuck genome in two independent hepatocellular carcinomas
✍ Scribed by R. Bruni; C. Argentini; E. D’Ugo; R. Giuseppetti; M. Rapicetta
- Publisher
- Springer Vienna
- Year
- 1997
- Tongue
- English
- Weight
- 257 KB
- Volume
- 142
- Category
- Article
- ISSN
- 1432-8798
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The chromosomal sites of woodchuck hepatitis virus (WHV) DNA integration were identified in a woodchuck hepatocellular carcinoma-derived cell line (WH257GE 10) by the in situ hybridization technique using 'H-labelled WHV whole genome (WHV 2) as a probe. The C-banded chromosome spreads from WH257GE 1
## Abstract This study aimed to determine hepatitis B virus (HBV) mutations associated independently with the risk of hepatocellular carcinoma (HCC), as adjusted with other mutations in the preS and core promoter regions of HBV genotypes B and C. One hundred and forty HBV‐infected patients with HCC
To elucidate critical genetic elements in the development of hepatocellular carcinoma associated with hepatitis B virus DNA integration, a single integrant in hepatocellular carcinoma cells and one species of multiple integrants in hepatocytes, both obtained from the same patient, were compared stru