## Abstract White matter lesions are thought to result from chronic cerebral ischemia and constitute a core pathology of subcortical vascular dementia. This rarefaction has been known to be associated with microglial activation. We investigated whether minocycline, a microglial inhibitor, attenuate
โฆ LIBER โฆ
White matter change in an animal model of chronic cerebral hypoperfusion
โ Scribed by Kurumadani, T.; Takeda, M.; Kudo, T.; Ikura, Y.; Hariguchi, S.; Nishimura, T.
- Book ID
- 124118325
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 166 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0197-4580
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## Abstract We sought to establish a mouse model of subcortical ischemic vascular dementia (SIVD) that develops predominant white matter (WM) injury and cognitive dysfunction induced by chronic cerebral hypoperfusion. Adult C57Bl/6 male (n = 48) mice were subjected to bilateral common carotid arter