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Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat

✍ Scribed by Hideaki Wakita; Hidekazu Tomimoto; Ichiro Akiguchi; Akinori Matsuo; Jin-Xi Lin; Masafumi Ihara; Patrick-L McGeer

Book ID
113997717
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
1008 KB
Volume
924
Category
Article
ISSN
0006-8993

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Minocycline attenuates white matter dama
Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion
✍ Kyung-Ok Cho; Hyen O. La; Young-Jin Cho; Ki-Wug Sung; Seong Y. Kim πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 629 KB

## Abstract White matter lesions are thought to result from chronic cerebral ischemia and constitute a core pathology of subcortical vascular dementia. This rarefaction has been known to be associated with microglial activation. We investigated whether minocycline, a microglial inhibitor, attenuate