Adrenomedullin preserves white matter integrity after chronic cerebral hypoperfusion in mice
โ Scribed by Takakuni Maki; Yushi Fujita; Masafumi Ihara; Keiko Nishio; Hidefumi Ito; Ryosuke Takahashi; Hidekazu Tomimoto; Takuo Nanbu; Hideki Yokoi; Kazutoshi Miyashita; Hiroshi Ito; Hiroshi Arai; Kazuwa Nakao
- Book ID
- 116776981
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 86 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0168-0102
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract We sought to establish a mouse model of subcortical ischemic vascular dementia (SIVD) that develops predominant white matter (WM) injury and cognitive dysfunction induced by chronic cerebral hypoperfusion. Adult C57Bl/6 male (n = 48) mice were subjected to bilateral common carotid arter
## Abstract White matter lesions are thought to result from chronic cerebral ischemia and constitute a core pathology of subcortical vascular dementia. This rarefaction has been known to be associated with microglial activation. We investigated whether minocycline, a microglial inhibitor, attenuate