Well-Defined N-Heterocyclic Carbene Based Ruthenium Catalysts for Direct Amide Synthesis from Alcohols and Amines
β Scribed by Zhang, Yao; Chen, Cheng; Ghosh, Subhash Chandra; Li, Yongxin; Hong, Soon Hyeok
- Book ID
- 121014483
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 840 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0276-7333
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π SIMILAR VOLUMES
A well-defined N-heterocyclic carbene based ruthenium complex was developed as a highly active precatalyst for the direct amide synthesis from alcohols and secondary amines. Notably, reaction of 1-hexanol and dibenzylamine afforded 60% of the corresponding amide using our catalytic system, while no
## Abstract Amides are synthesized directly from alcohols and amines in high yields using an __in situ__ generated catalyst from easily available ruthenium complexes such as the (__p__βcymene)ruthenium dichloride dimer, [Ru(__p__βcymeme)Cl~2~]~2~, or the (benzene)ruthenium dichloride dimer, [Ru(ben