Wang Linker Free of Side Reactions
✍ Scribed by Castro, Vida; Rodriguez, Hortensia; Albericio, Fernando
- Book ID
- 120316956
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 914 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
A new linker based on a chroman system is described for the side-chain anchoring of Arg and other guanidine-containing molecules. The system is compatible with the Fmoc/tBu solid-phase strategy, because the release of the final product is achieved by treatment with TFA in the presence of scavengers.
## Abstract A double side‐reaction, consisting in the formation of Fmoc‐β‐Ala‐OH and Fmoc‐β‐Ala‐AA‐OH, during the preparation of Fmoc protected amino acids (Fmoc‐AA‐OH) with Fmoc‐OSu is discussed. Furthermore, the new Fmoc‐2‐MBT reagent is proposed for avoiding these side‐reactions as well as the f