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Chromatography- and Lyophilization-Free Synthesis of a Peptide-Linker Conjugate

✍ Scribed by Magano, Javier; Bock, Brandon; Brennan, John; Farrand, Douglas; Lovdahl, Michael; Maloney, Mark T.; Nadkarni, Durgesh; Oliver, Wendy K.; Pozzo, Mark J.; Teixeira, John J.; Wang, Jian; Rizzo, John; Tumelty, David


Book ID
121455945
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
666 KB
Volume
18
Category
Article
ISSN
1083-6160

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## Abstract A new cysteine‐based disulfide linker for Fmoc solid phase peptide synthesis was developed (Fmoc‐Cys(3‐mercapto‐3‐methylbutanoic acid)OPp) that allows the on‐resin assembly and side chain deprotection of cyclic peptides. Model peptides and a cyclic peptide library of the structure [a‐a‐