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W1942 Bevacizumab Induces Cellular Senescence in Colorectal Cancer In Vitro and In Vivo

✍ Scribed by Ho, Shirley; Chan, Justin M.; Tang, Michelle J.; Tai, Isabella T.

Book ID
122026273
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
50 KB
Volume
136
Category
Article
ISSN
0016-5085

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## Abstract Vascular endothelial growth factor (VEGF) inhibitors, such as bevacizumab, have improved outcomes in metastatic colorectal cancer (CRC). Recent studies have suggested that VEGF can delay the onset of cellular senescence in human endothelial cells. As VEGF receptors are known to be upreg