## Introduction: Epidemiological data suggests that 5-aminosalicylic acid (5-asa), a nonsteroidal antiinflammatory drug used in the treatment of inflammatory bowel diseases, prevents colorectal cancer development in these patients, although the mechanisms remain incompletely understood. ## Methods
M1190 5-Aminosalicylic Acid Induces Colorectal Cancer Cell Death In Vitro and In Vivo
โ Scribed by Koelink, Pim J.; Langers, Alexandra; De Vos tot Nederveen Cappel, Wouter H.; Lamers, Cornelis B.; Hommes, Daniel W.; Verspaget, Hein W.
- Book ID
- 123527449
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 51 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0016-5085
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5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speciยฎc prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti
## Abstract A hallmark of cancer cells is an ability to evade apoptosis. Overexpression and/or activating mutations of prosurvival molecules such as the Xโlinked inhibitor of apoptosis (XIAP) contribute to this inappropriate cell survival. Our objectives were to investigate the effects of downregul