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5-aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes

✍ Scribed by Pim J. Koelink; Marij A.C. Mieremet-Ooms; Willem E. Corver; Kamila Wolanin; Daniel W. Hommes; Cornelis B.H.W. Lamers; Hein W. Verspaget

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
799 KB
Volume
16
Category
Article
ISSN
1078-0998

No coin nor oath required. For personal study only.

✦ Synopsis

Introduction:

Epidemiological data suggests that 5-aminosalicylic acid (5-asa), a nonsteroidal antiinflammatory drug used in the treatment of inflammatory bowel diseases, prevents colorectal cancer development in these patients, although the mechanisms remain incompletely understood.

Methods and results:

Here we report that 5-asa prevents growth of several colorectal cancer cell lines by interfering in the cell cycle, i.e., an s-phase and g2/m phase arrest, dependent on 5-asa dosage and concentration, together with an increased mitotic index. in addition, prolonged cell cycle arrest by repeated 5-asa treatment induced apoptosis and caused abnormal spindle organization leading to mitotic catastrophe, another form of cell death.

Conclusion:

These observations illustrate that 5-asa has chemopreventive and chemotherapeutic properties.

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