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VEGF Inhibitors Induce Cellular Senescence in Colorectal Cancers

✍ Scribed by Mohammad R. Hasan; Shirley Ho; David A. Owen; Isabella T. Tai

Book ID
119431873
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
43 KB
Volume
140
Category
Article
ISSN
0016-5085

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Inhibition of VEGF induces cellular sene
Inhibition of VEGF induces cellular senescence in colorectal cancer cells
✍ Mohammad R. Hasan; Shirley H. Y. Ho; David A. Owen; Isabella T. Tai πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 French βš– 774 KB

## Abstract Vascular endothelial growth factor (VEGF) inhibitors, such as bevacizumab, have improved outcomes in metastatic colorectal cancer (CRC). Recent studies have suggested that VEGF can delay the onset of cellular senescence in human endothelial cells. As VEGF receptors are known to be upreg