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Volume regulation in the erythrocyte of the little skate,Raja erinacea

✍ Scribed by Goldstein, Leon

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 650 KB
Volume: 252
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402520414

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✦ Synopsis

Elasmobranchs maintain a high concentration of NaCl in their extracellular fluid, which is matched intracellularly by organic solutes such as p-amino acids. Hypo-osmotic stress causes a volume regulatory response involving a n increased efflux of p-amino acids. The mechanism of transmembrane signaling involved in this response is under investigation in skate RBC. The effects of hypo-osmotic stress on taurine efflux are mimicked by activating protein kinase C with phorbol ester or elevated cellular Cat ', Hypo-osmotic stress induces an immediate elevation in cellular production of the protein kinase C activator diacylglycerol. These results suggest that activation of protein kinase C is involved in the volume regulatory response of skate RBC to hypoosmotic stress.

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