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β-Alanine oxidation in the liver of the little skate,Raja erinacea

✍ Scribed by Leech, Anthony R. ;Goldstein, Leon

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
446 KB
Volume
225
Category
Article
ISSN
0022-104X

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✦ Synopsis

The pathway of p-alanine (BALA) oxidation was examined in the liver of the little skate, Raja erinacea. BALA oxidation in liver slices was reduced by inhibitors of transamination and mitochondria1 electron transport. Experiments with liver homogenates indicated that BALA was oxidized by a twostep process: (1) transamination of BALA to malonate semialdehyde (MSA) and

(2) conversion of MSA to COz and acetate. Increases in BALA oxidation during osmotic stress are probably mediated by changes in substrate concentration rather than alterations in enzyme levels.

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