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Voltage-gated sodium channel-associated proteins and alternative mechanisms of inactivation and block

✍ Scribed by Mitchell Goldfarb

Publisher
Springer
Year
2011
Tongue
English
Weight
384 KB
Volume
69
Category
Article
ISSN
1420-682X

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## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi