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Structure, function and pharmacology of voltage-gated sodium channels

✍ Scribed by Helena Denac; Meike Mevissen; Günter Scholtysik


Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
224 KB
Volume
362
Category
Article
ISSN
0028-1298

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Anti-GM1 antibodies can block neuronal v
✍ Frank Weber; Reinhardt Rüdel; Peter Aulkemeyer; Heinrich Brinkmeier 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB

Anti-GM1 antibodies, frequently found in the serum of patients with Guillain-Barré syndrome (GBS), have been suggested to interfere with axonal function. We report that IgG anti-GM1 antibodies, raised in rabbits, can reversibly block the voltage-gated Na(+) channels of nerve cells, thus causing a re