Volatile N-nitrosamines in mainstream cigarette smoke: occurrence and formation

✍ Scribed by Tricker, A.R. ;Preussmann, R.

• Book ID: 104654863
• Publisher: Springer-Verlag
• Year: 1992
• Tongue: English
• Weight: 656 KB
• Volume: 70-70
• Category: Article
• ISSN: 1432-1440
• DOI: 10.1007/bf00184663

✦ Synopsis

Analytical data is presented for the occurrence of the three major volatile N-nitrosamines in cigarette tobacco and mainstream smoke, namely N-nitrosodimethylamine (NDMA),- N-nitrosoethylmethylamine (NEMA) and N-nitrosopyrrolidine (NPYR) as well as for the occurrence of the corresponding precursor amines and non-volatile N-nitrosamino acids in tobacco. Experimental studies using the C20 reference cigarette show that NPYR present in mainstream smoke results from direct transfer of preformed NPYR (ca. 1.5%), decarboxylation of N-nitrosoproline in tobacco (ca. 10%), pyrolytic nitrosation of pyrrolidine in tobacco (ca. 37%) and concerted decarboxylation/nitrosation of proline (ca. 52%) during tobacco pyrolysis.