Vitamin D3 Metabolites III. Synthesis and X-ray analysis of 1α, 25-dihydroxycholesterol
✍ Scribed by Thomas A. Narwid; John F. Blount; Jerome A. Iacobelli; Milan R. Uskoković
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- German
- Weight
- 630 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
Die Synthese von 1α, 25‐Dihydroxycholesterin (1) aus 3‐O‐Acetyl‐25‐hydroxy‐cholesterin (2) in 18proz. Gesamtausbeute wird beschrieben. Die Struktur von 1 wurde durch Röntgen‐Strahlendiffraktion bewiesen.
📜 SIMILAR VOLUMES
## Abstract The 1α, 25, 26‐trihydroxy metabolite of vitamin D~3~, isolated from bovine serum, was shown to possess the (25 __S__)‐configuration by HPLC. comparison of the 1, 3, 26‐triacetate derivative with authentic (25 __R__)‐ and (25 __S__)‐samples. The convergent synthesis of (25 __R__)‐1α, 25,
1␣,25-dihydroxyvitamin D 3 (1␣,25(OH) 2 D 3 ), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D receptor can directly regulate gene expression by binding to