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(25 S)-1α, 25, 26-Trihydroxycholecalciferol, a New Vitamin D3 Metabolite: Synthesis and Absolute Stereochemistry at C(25)

✍ Scribed by John J. Partridge; Shian-Jan Shiuey; Naresh K. Chadha; Enrico G. Baggiolini; Bernard M. Hennessy; Milan R. Uskoković; Joseph L. Napoli; Timothy A. Reinhardt; Ron L. Horst

Publisher: John Wiley and Sons
Year: 1981
Tongue: German
Weight: 189 KB
Volume: 64
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19810640718

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✦ Synopsis

Abstract

The 1α, 25, 26‐trihydroxy metabolite of vitamin D~3~, isolated from bovine serum, was shown to possess the (25 S)‐configuration by HPLC. comparison of the 1, 3, 26‐triacetate derivative with authentic (25 R)‐ and (25 S)‐samples. The convergent synthesis of (25 R)‐1α, 25, 26‐ and (25 S)‐1α, 25, 26‐trihydroxycholecalciferols (10a) and (10b) has been accomplished.

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