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New Derivatives of 1α,25-Dihydroxy-19-norvitamin D3 with Two Substituents at C-2: Synthesis and Biological Activity.

✍ Scribed by Masato Shimizu; Yukiko Iwasaki; Mika Shimazaki; Youhei Amano; Keiko Yamamoto; Wolfgang Reischl; Sachiko Yamada


Publisher
John Wiley and Sons
Year
2005
Weight
12 KB
Volume
36
Category
Article
ISSN
0931-7597

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✍ Dr. Lieve Verlinden; Prof. Annemieke Verstuyf; Dr. Guy Eelen; Prof. Roger Bouill 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB

## Abstract An improved synthetic route to 1α,25‐dihydroxyvitamin D~3~ des‐side chain analogues **2 a** and **2 b** with substituents at C18 is reported, along with their biological activity. These analogues display significant antiproliferative effects toward MCF‐7 breast cancer cells and prodiffe