ChemInform Abstract: Copper-Mediated Alkylation of Vitamin D C-Ring. Synthesis of C11- Functionalized 1α,25-Dihydroxyvitamin D3.

✍ Scribed by M. TORNEIRO; Y. FALL; L. CASTEDO; A. MOURINO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 36 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199751086

✦ Synopsis

Copper-Mediated Alkylation of Vitamin D C-Ring. Synthesis of C11-Functionalized 1α,25-Dihydroxyvitamin D3.

-The functionalization of C-11 of CD-ring fragments of vitamin D3, e.g. (I), with organocopper reagents is studied. The application results in an efficient, convergent synthesis of the calcitriol analogue (XIII). -(TORNEIRO, M.;