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Vitamin D receptor polymorphisms and risk of colorectal adenomas (United States)

✍ Scribed by SueAnn Ingles; Jun Wang; Gerhard A. Coetzee; Eric R. Lee; Harold D. Frankl; Robert W. Haile

Book ID
110299474
Publisher
Springer Netherlands
Year
2001
Tongue
English
Weight
100 KB
Volume
12
Category
Article
ISSN
0957-5243

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## Abstract Vitamin D receptor (VDR) activation inhibits proliferation and angiogenesis in the colorectal epithelium, and inhibits metastasis of colorectal tumors. Polymorphisms in the __VDR__ gene alter receptor cellular levels and functioning, and may confer altered susceptibility to colorectal n