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Vitamin D and estrogen receptor gene polymorphisms and the risk of colorectal cancer in Bulgaria

✍ Scribed by Tanya Kadiyska; Toma Yakulov; Radka Kaneva; Dimitar Nedin; Alexandrina Alexandrova; Antonina Gegova; Alexey Savov; Vanio Mitev; Ivo Kremensky

Publisher
Springer
Year
2006
Tongue
English
Weight
162 KB
Volume
22
Category
Article
ISSN
0179-1958

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## Abstract Vitamin D receptor (VDR) activation inhibits proliferation and angiogenesis in the colorectal epithelium, and inhibits metastasis of colorectal tumors. Polymorphisms in the __VDR__ gene alter receptor cellular levels and functioning, and may confer altered susceptibility to colorectal n