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Vitamin D receptor poly(A) microsatellite and colorectal cancer risk in Caucasians

✍ Scribed by Jana Flügge; Gabriele Laschinski; Ivar Roots; Solveigh Krusekopf

Publisher: Springer
Year: 2008
Tongue: English
Weight: 169 KB
Volume: 24
Category: Article
ISSN: 0179-1958
DOI: 10.1007/s00384-008-0617-7

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## Abstract Vitamin D receptor (VDR) activation inhibits proliferation and angiogenesis in the colorectal epithelium, and inhibits metastasis of colorectal tumors. Polymorphisms in the __VDR__ gene alter receptor cellular levels and functioning, and may confer altered susceptibility to colorectal n