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Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment

✍ Scribed by Stephen W. Byers; Tracey Rowlands; Marcy Beildeck; Yong-Sik Bong

Publisher
Springer
Year
2011
Tongue
English
Weight
239 KB
Volume
13
Category
Article
ISSN
1389-9155

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## Abstract Vitamin D receptor (VDR) activation inhibits proliferation and angiogenesis in the colorectal epithelium, and inhibits metastasis of colorectal tumors. Polymorphisms in the __VDR__ gene alter receptor cellular levels and functioning, and may confer altered susceptibility to colorectal n