𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Virus-augmented tumor transplantation antigens: Evidence for a helper antigen mechanism

✍ Scribed by Charles W. Boone; Meera Paranjpe; Thomas Orme; Ronald Gillette

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
573 KB
Volume
13
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

While the homogenate of a transplantable SV40‐transformed fibrosarcoma of BALB/c mice was without tumor transplantation antigen (TTA) activity, a homogenate of the same tumor cells after infection with influenza virus or vesicular stomatitis virus retained TTA activity to a degree approaching that of whole cells. Ultraviolet inactivation of the virus in the homogenate did not affect its TTA activity. Strong evidence for a helper antigen mechanism was provided by two findings: (1) Mice made tolerant to influenza virus could no longer be made tumor‐immune with the virus‐infected tumor homogenate, and (2) priming mice with three weekly injections of egg‐grown influenza virus abrogated the ability of the virus‐infected tumor homogenate to produce tumor immunity when it was given during the fourth week. Although tumor‐cell homogenates would not induce tumor immunity, they would elicit a delayed hypersensitivity reaction in the foot pad. A working hypothesis that correlates all of the findings is proposed.

📜 SIMILAR VOLUMES

Studies on the polyoma-virus-induced tum
Studies on the polyoma-virus-induced tumor-specific transplantation antigen (TSTA) - does middle or large T-antigen play a role?
✍ Tina Dalianis; Torbjörn Ramqvist; George Klein 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 347 KB

Mice and rats could be immunized against the polyoma-virus-induced tumor-specific transplantation antigen (TSTA) by repeated inoculation of frozen or irradiated cells of an MT-cDNA-transformed rat cell line (2.8) that contains only the polyoma middle T-antigen, or by cells that carried a host range

Evidence for virus-specific transplantat
Evidence for virus-specific transplantation antigen in cells of lymphoid neoplasms induced by papovavirus sv40
✍ S. S. Tevethia 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 430 KB 👁 1 views

## Abstract Hamster lymphocyte leukemia and lymphosarcoma induced in vivo __by papova‐virus SV40 were tested for the presence of SV40‐specific transplantation antigen. The cells derived from lymphocytic leukemia (GD‐248) blocked primary SV40 oncogenesis__ in vivo and also immunized adult hamsters a

Cell-surface antigens of murine sarcoma-
Cell-surface antigens of murine sarcoma-virus-transformed non-producer cells: Further evidence for lack of transplantation immunity
✍ Joel S. Greenberger; John R. Stephenson; Tadao Aoki; Stuart A. Aaronson 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 629 KB

## Abstract Previous studies have indicated that cells transformed by murine sarcoma virus (MSV) in the absence of virus production lack detectable transplantation antigens. Recent findings that antibodies to a surface antigen associated with MSV‐transformed cells can be elicited by hyperimmunizati