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Studies on the polyoma-virus-induced tumor-specific transplantation antigen (TSTA) - does middle or large T-antigen play a role?

✍ Scribed by Tina Dalianis; Torbjörn Ramqvist; George Klein

Publisher: John Wiley and Sons
Year: 1984
Tongue: French
Weight: 347 KB
Volume: 34
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910340318

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✦ Synopsis

Mice and rats could be immunized against the polyoma-virus-induced tumor-specific transplantation antigen (TSTA) by repeated inoculation of frozen or irradiated cells of an MT-cDNA-transformed rat cell line (2.8) that contains only the polyoma middle T-antigen, or by cells that carried a host range mutant and expressed a full-length large T-antigen, but only non-functional N-terminal fragments of small and middle T. This shows that neither large T nor an intact middle T is necessary to elicit a polyoma tumor-specific graft rejection response. Either one of them is sufficient by itself.

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Vaccination against polyoma virus (PYV) tumors using vaccinia-PYV recombinants: A major tumor-specific transplantation antigen (TSTA) epitope resides within the C-terminal segment of middle-T protein

✍ M. P. Kieny; C. Gautier; C. Tomasetto; I. Kuhn; M. Hareuveni; P. Clertant; R. La 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 592 KB

## Abstract We previously reported that inoculation of rats with live vaccinia virus (VV) recombinants VVpyMT, VVpyLT expressing either the middle‐T (MT) or large‐T (LT) proteins of polyomavirus (PyV) can elicit immunity to challenge with syngeneic PyV‐tumor cells. We now report the results of cros