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Viral therapy: Prospects for protease inhibitors

✍ Scribed by Bruce D. Korant; Takae Towatari; Lucy Ivanoff; Steven Y. Pettewa Jr.; Joze Brzin; Brigita Lenarcic; Vito Turk

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 270 KB
Volume: 32
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240320202

No coin nor oath required. For personal study only.

✦ Synopsis

Antiviral activities of known protease inhibitors were assayed in virus-infected cell cultures. Some members of the cystatin superfamily, in particular chicken cystatin, were able to block virus replication. In a binding assay, using purified components, chicken and human cystatin were able to bind poliovirus protease with affinities which were reflected in their relative anitviral potencies. Prospects for application of protease inhibitors in clinical viral infections are discussed.

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