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Vincristine neuropathy in type I and type II charcot-marie-tooth disease (hereditary motor sensory neuropathy)

✍ Scribed by Igarashi, Masanori ;Thompson, Elizabeth I. ;Rivera, Gaston K.

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 827 KB
Volume: 25
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950250212

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✦ Synopsis

Abstract

A patient with Ewing's sarcoma and demyelinating type Charcot‐Marie‐Tooth disease (CMT) developed severe neuropathy after receiving a total vincristine dose of 6 mg. Recovery was slow and incomplete. A second patient with axonal type CMT developed moderate neuropathy but tolerated extended vincristine administration and recovered quickly. Possible underlying neuropathy should be excluded before vincristine treatment is begun by careful examination including inspection of the feet, followed by electrophysiologic studies as indicated. In demyelinating CMT, vincristine should be avoided; in axonal form cautious use may be considered. © 1995 Wiley‐Liss, Inc.

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