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Severe vincristine neuropathy in charcot-marie-tooth disease type 1A

✍ Scribed by William D. Graf; Phillip F. Chance; M. William Lensch; Lilly J. Eng; Hillary P. Lipe; Thomas D. Bird

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
566 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

A general predisposition for vincristine-related neuropathy has been observed in persons with a family history of hereditary neuropathies.

METHODS.

In a retrospective case series, we investigated the possible association between the DNA rearrangement found in patients with Charcot-Marie-Tooth Disease Type 1A (CMTlA) and susceptibility to the neurotoxicity of vincristine. In selected patients and family members, we performed electrodiagnostic studies and analyzed DNA samples for 17~11.2-12 duplication associated with CMTlA.

RESULTS.

We describe three families with autosomal dominant CMT1, among whom a family member with a neoplastic disease suffered rapid onset, severe neuropathy after receiving initial doses of vincristine as a part of a routine chemotherapy protocol. All three families had at least one affected family member with 17~11.2-12 duplication.

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