To identify the roles of pyridoxine-5'-phosphate (PNP) oxidase in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PNP oxidase expression was conducted. PNP oxidase immunoreactivity in a preseizure group of seizure-sensitive (SS) gerbils
✦ LIBER ✦
Vigabatrin inhibits pyridoxine-5′-phosphate oxidase, not pyridoxal kinase in the hippocampus of seizure prone gerbils
✍ Scribed by Sung-Jin An; Seung-Kook Park; In Koo Hwang; Soo-Young Choi; Oh-Shin Kwon; Moo Ho Won; Tae-Cheon Kang
- Book ID
- 117409989
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 175 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0197-0186
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## Abstract In this study, we investigated whether the expression of pyridoxal kinase (PLK) and pyridoxine‐5′‐phosphate oxidase (PNPO) are altered following long‐term potentiation (LTP) induction, and whether Tat‐PLK and Tat‐PNPO transductions affect LTP induction and paired‐pulse responses in the