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Pyridoxine 5′-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus

✍ Scribed by Sung-Eun Kwak; Ji-Eun Kim; Dae-Won Kim; Oh-Shin Kwon; Soo-Young Choi; Tae-Cheon Kang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
945 KB
Volume
19
Category
Article
ISSN
1050-9631

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✦ Synopsis

Abstract

In this study, we investigated whether the expression of pyridoxal kinase (PLK) and pyridoxine‐5′‐phosphate oxidase (PNPO) are altered following long‐term potentiation (LTP) induction, and whether Tat‐PLK and Tat‐PNPO transductions affect LTP induction and paired‐pulse responses in the rat dentate gyrus (DG). PNPO immunoreactivity was markedly increased in dentate granule cells after the induction of LTP, but that of PLK was not. Tat‐PNPO (20 and 200 μg/kg), but not Tat‐PLK or vitamin B~6~ precursors, treatments, increased the efficiency of high frequency stimulus‐induced potentiation of populations spike amplitude when compared with saline‐, or Tat‐protein‐treated animals. These changes correlated with the alterations in PNPO activity and its immunoreactivity. In addition, Tat‐PNPO transduction increased paired‐pulse facilitation but had no effect on the fast and late paired‐pulse inhibitions. These findings suggest that PNPO may play a role in activity‐dependent regulation of PLP level in the brain, which is involved in LTP induction and paired‐pulse facilitation but not in enhancement of GABAergic inhibition. © 2008 Wiley‐Liss, Inc.

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