Vicarious nucleophilic Substitution of Hydrogen in Pteridine derivatives
✍ Scribed by Prof. Dr. M. Mąkosza; Dr. S. Ostrowski
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 315 KB
- Volume
- 330
- Category
- Article
- ISSN
- 1615-4150
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📜 SIMILAR VOLUMES
## Abstract Azulene reacts with carbanions bearing a leaving group according to the vicarious nucleophilic substitution (VNS) scheme. Treatment of 6‐chloroazulene with such carbanions affords the VNS reaction and nucleophilic aromatic substitution (S~N~Ar) products. magnified image
Hydrogens located at activated positions in electrophilic arenes, e.g. ortho and para hydrogens in nitrobenzenes, can be replaced with a nucleophile moiety provided there is at least one nucleofuge X connected to the nucleophilic centre. As the group really leaving in this hydrogen substitution proc