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Vicarious nucleophilic Substitution of Hydrogen in Pteridine derivatives

✍ Scribed by Prof. Dr. M. Mąkosza; Dr. S. Ostrowski


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
315 KB
Volume
330
Category
Article
ISSN
1615-4150

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## Abstract Azulene reacts with carbanions bearing a leaving group according to the vicarious nucleophilic substitution (VNS) scheme. Treatment of 6‐chloroazulene with such carbanions affords the VNS reaction and nucleophilic aromatic substitution (S~N~Ar) products. magnified image

Vicarious nucleophilic substitution of h
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Hydrogens located at activated positions in electrophilic arenes, e.g. ortho and para hydrogens in nitrobenzenes, can be replaced with a nucleophile moiety provided there is at least one nucleofuge X connected to the nucleophilic centre. As the group really leaving in this hydrogen substitution proc