Vicarious nucleophilic substitution of hydrogen in nitrophenyl toluenesulfonates
✍ Scribed by Mieczysław Ma̧kosza; Tadeusz Ziobrowski; Mikhail Serebriakov; Andrzej Kwast
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 710 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
## Abstract Azulene reacts with carbanions bearing a leaving group according to the vicarious nucleophilic substitution (VNS) scheme. Treatment of 6‐chloroazulene with such carbanions affords the VNS reaction and nucleophilic aromatic substitution (S~N~Ar) products. magnified image
Hydrogens located at activated positions in electrophilic arenes, e.g. ortho and para hydrogens in nitrobenzenes, can be replaced with a nucleophile moiety provided there is at least one nucleofuge X connected to the nucleophilic centre. As the group really leaving in this hydrogen substitution proc