Regulation of platelet heparanase during
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Nathan S. Ihrcke; William Parker; Kathryn J. Reissner; Jeffrey L. Platt
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Article
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1998
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John Wiley and Sons
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English
β 296 KB
Heparan sulfate is rapidly degraded by an endoglycosidase (heparanase) secreted by activated platelets. Since the cleavage and release of heparan sulfate would profoundly alter the local physiology of the endothelium, platelet heparanase activity should be tightly regulated. Consistent with this hyp