BMI1 as a novel target for drug discover
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Liangxian Cao; Jenelle Bombard; Katherine Cintron; Josephine Sheedy; Marla L. We
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Article
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2011
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John Wiley and Sons
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English
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Growing evidence has demonstrated that clonogenic cancer stem (initiating) cells are responsible for tumor regrowth and disease relapse. Bmi-1 plays a critical role in the self-renewal of adult stem cells. The Bmi-1 protein is elevated in many types of cancers, and experimental reduction of Bmi-1 pr