## Abstract The influence of age at time of DMBA administration on (l) the histopathogenesis and site of mammary tumor origin and (2) the precancerous nature of DMBAβinduced mammary dysplasias was examined in Lewis rats between 25 and 200 days of age. Rats were killed at various times after carcino
Variations dependent on Age and Diet in the Metabolism of 7,12-Dimethylbenz[a]-anthracene by Rat Liver Homogenates
β Scribed by SIMS, P.; GROVER, P. L.
- Book ID
- 109659707
- Publisher
- Nature Publishing Group
- Year
- 1967
- Tongue
- English
- Weight
- 226 KB
- Volume
- 216
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/216077a0
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π SIMILAR VOLUMES
Wistar rats of different age and sex received a single intragastric instillation of ## 7,12-dimethylbenz(a)anthracene ( D M B A ) . During the following 16 months, 136 of 284 rats developed 182 tumors, of which haw were malignant. Among 98 untreated controls, 8 rats developed tumors, of which 4 w
Effect of the induction of drug metabolizing enzymes by Sudan I11 on the in vivo and in vitro genotoxicity elicited by 7,12-dimethylbenz(a1anthracene (DMBA) was investigated. A significant suppression of DMBA-induced micronucleated reticulocytes was observed in C57BL/6 mice treated with Sudan I11 in