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Effect of age and sex on the development of neoplasms in wistar rats receiving a single intragastric instillation of 7,12-dimethylbenz(a)anthracene

โœ Scribed by D. R. Meranze; M. Gruenstein; M. B. Shimkin

Publisher
John Wiley and Sons
Year
1969
Tongue
French
Weight
375 KB
Volume
4
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Wistar rats of different age and sex received a single intragastric instillation of

7,12-dimethylbenz(a)anthracene ( D M B A )

. During the following 16 months, 136 of 284 rats developed 182 tumors, of which haw were malignant. Among 98 untreated controls, 8 rats developed tumors, of which 4 were malignant. Among the youngest groups (8-15 days) exposed to DMBA, fibroadenoma of the breast in females and subcutaneous sarcoma in both sexes were the most frequent. Among young adult females (6-8 weeks), mammary carcinoma predominated; older females (26 week5) had less breast tumors, Among adult males, epidermoid carcinoma and papilloma of the skin were most frequent. Castration suppressed development of breast canwr.

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